– 10 weeks or later into pregnancy we take a small amount of your blood for testing.
– Your blood sample is sent to the Vision Laboratory to be analysed.
– Your results are sent back to us within 5-7 business days from receipt of sample.
When you’re pregnant, your blood contains fragments of your baby’s DNA.
Vision Prenatal Test is a new type of test that analyses this DNA in a sample of your blood to assess the risk of Down syndrome (trisomy 21) and two other genetic conditions, trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome).
For all women traditional screening tests can miss as many as 15% of Down syndrome cases in pregnant women.
Harmony was developed to be a more accurate prenatal Down syndrome screening test for all women, regardless of age or risk. It is a new DNA-based blood test that has been extensively tested in pregnant women both over and under 35.
Conventional screening will detect approximately 70-80% of pregnancies with Down syndrome.
Vision has a false positive rate of less than 0.1% compared to 5% with conventional screening.
This means that the Vision test detects more pregnancies with Down syndrome but also reduces the risk of unnecessary amniocentesis.
Vision Prenatal Test requires a single blood sample from your arm and can be done as early as 10 weeks or later in pregnancy. Results are usually available within a week. Other commonly used tests for Down syndrome are performed later in pregnancy and require multiple clinic visits.
The greater accuracy and low false-positive rate of Vision compared to the traditional tests minimises the number of high risk results. Therefore fewer women will need follow up testing using an invasive procedure, such as amniocentesis.
Vision Prenatal Test can also be used to evaluate X and Y sex chromosomes as early as 10 weeks.
You have the option to test for conditions caused by having an extra or missing copy of the X or Y chromosomes, including Turner and Klinefelter syndromes (This is only available for singleton pregnancies).
Does a low risk result mean that the baby does not have Down Syndrome?
No, any screening test carries a risk of a ‘false negative’ however the risk of this happening with the Vision is much lower than with conventional Down screening.
If I have a high risk result does that mean that the baby’s chromosomes are abnormal?
No, not necessarily. It means that there is a higher risk and you will be offered the option of amniocentesis to assess the chromosomes directly. You will be offered support and counselling to help you reach that decision.
The Vision Non Invasive Prenatal Test and technology can also be applied to twin pregnancies but is not suitable in the case of a vanishing twin.
3 out of 100 women will require a repeat test. We receive a result in approximately two thirds of these samples. Patients will not be charged if we are unable to obtain a result.
Price – £399 bloods & consultation.
If you would prefer a home visit to have your bloods taken please let us know and this can be arranged for an additional charge.
If you require a reassurance scan please let us know. This is an additional cost £39.
Outlook Newborn test – £295
A simple swab test that allows you to glimpse into your child’s future health by screening for four conditions.
Milk is the first and most important nutritional ingredient for every baby, containing components such as proteins, fats, carbohydrates, minerals and vitamins that are essential for growth and development. Lactose is the main carbohydrate found in dairy products and is frequently hailed as a trigger for digestive problems.
Lactose intolerance affects around 1 in 50 people of Northern European descent and this figure increases substantially for other ethnic groups, such as African and Asian4.
Lactose intolerance is caused by the body not producing enough of the enzyme lactase, which digests lactose. As a result, the lactose will remain in the gut longer, which will enable the bacteria to ferment and lead to a build-up of gas. This commonly causes symptoms such as wind, bloating, stomach cramps and diarrhoea. These symptoms are relatively non-specific and can appear anywhere between 15 minutes to two hours after the last intake of milk or dairy, making it difficult to accurately diagnose. The symptoms of lactose intolerance can be reduced by limiting the intake of foods that are considered to be rich in lactose. It is also possible to take lactase tablets at meal times to improve lactose digestion.
Testing for lactose intolerance
Although there are several ways to test for lactose intolerance, most tests are often harmful and painful as these tests are based on provoking symptoms. Alternatively, these tests can involve taking a biopsy of the small intestine and are therefore often considered to be overly invasive.
Our simple test, Outlook, provides an easy and non-stressful alternative for you to find out if your child is predisposed to lactose intolerance. This genetic test can be performed before any symptoms of intolerance become evident. Therefore, with an appropriate diet, it is possible to prevent symptoms from ever appearing.
Coeliac disease is characterised as a sensitivity to gluten and is the most common autoimmune disease, with around 1 in every 200 people afflicted worldwide1.
Gluten is a protein found in the grains of wheat, barley and rye, and is one of the most common foods eaten around the world. However, some people can become hypersensitive to the presence of gluten, which may cause an abnormal reaction of the immune system against the small intestine.
This reaction can cause diarrhoea, abdominal swelling, cramps, nausea and in some cases lead to stunted growth. Longer term, coeliac disease causes damage to the small intestine, the section of the digestive system that absorbs nutrients from food.
The bitter taste test identifies a person’s individual sensitivity to bitter tasting foods. Sensitivity to bitter tastes is believed to be an evolutionary phenotype that arose through natural selection, in order to prevent us from consuming toxic plants. However, it can cause a reaction to common foods such as sprouts, cabbage, broccoli and other cruciferous vegetables that contain bitter-tasting compounds called glucosinolates.
In developed countries, approximately 1 in every 300 children show severe or profound deafness at birth, or during early childhood5, 6.
Several studies of deaf children have indicated that exposure to aminoglycoside antibiotics can lead to substantial hearing loss in 13-66% of cases7. Deafness has long-term implications for children in terms of communication skills, educational achievement, and overall quality of life.
Specific types of antibiotics called aminoglycosides are known to cause damage to the inner parts of the ear, leading to partial deafness in susceptible children. It is estimated that there are 1 in 500 children that carry a certain mitochondrial mutation (m.1555A >G), that predisposes them to rapid and permanent hearing loss after just one single dose of these antibiotics